Known as the “weekend pill” for its long lasting effects, it’s the active ingredient in Cialis. Medically approved and clinically proven to increase blood flow to the penis for up to 36 hours. Have a great weekend!

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Erections really aren’t that easy. For a lot of younger men as well. About 40% of men have erection difficulties by age 40. But help is here.


It works by inhibiting an enzyme known as PDE5 associated with muscle contraction in your penis. Tadalafil allows the blood vessels to relax and expand, leading to increased blood flow into the penis. Which means easier erections for most men. You’ll still need to be sexually stimulated though. So get in the mood! Find out more in ERECTIONS 101.


Howeffectiveis it?

The vast majority of men get the results they want from Tadalafil - the ability to get a strong erection for up to 36 hours.

Light some candles, put on some Barry White, game face on. You’ve got plenty of time.

How effective is it?

Why has hard got harder?

Your brain, heart, hormones and a few other bits and bobs all need to come together – this can be tricky at any age. Sometimes these things don’t gel so well, and you can’t get or stay hard enough to have satisfactory sex - this is known as erectile dysfunction. Tadalafil is one option for men with ED, whatever the cause, it usually helps.

Is this Cialis?

It’s exactly the same active ingredient as Cialis. Just without the branding. Rest assured you’re getting the same results.



If prescribed, you still need to be sexually aroused for it to work, so everything needs to be exciting. You’ve got this.


Take a pill an hour before you want to have sex. Tadalafil starts to work within 30 mins and maximum erection potential happens around the 2 hour mark.


Tadalafil can last up to 36 hours! So absolutely no need to rush. You’ve got all weekend! Happy days.


What causes ED?

There are many causes of ED, generally split into psychological or organic/psychological causes (such as medications, hormonal, neurovascular, anatomical factors). In many patients it can be a combination of factors, and so we advise having a checkup by a doctor. We give comprehensive guidance on what you should have checked with our prescription message.

What I need to know about Tadalafil?

Many men prefer Tadalafil in cases where Sildenafil is not as effective or where they want longer-lasting effects (upto 36 hours, sometimes more). Tadalafil, also known as the ‘weekend pill’ is particularly handy in case you are planning a couple of frisky sessions with your partner or a romantic getaway over the weekend. We generally recommend Tadalafil for men who prefer spontaneous erections and prefer making love more than twice a week. One tablet of tadalafil would be effective for 36 hours and so reduces the need for you to take a daily dose if you wish to engage in sexual activity more often!

Interestingly, a study comparing the PDE5 ED drugs has shown tadalafil 10mg tablets to have a superior tolerability profile, with the lowest frequency of adverse events versus the other PDE5 inhibitors. For men looking for something more short-acting and “as and when needed” Sildenafil might be the treatment of choice. For men looking for a longer, faster and more spontaneous erection and a more attractive side-effect profile, Tadalafil might be your best option. Gents, the decision is yours!

Subsequent Tadalafil doses should be adjusted according to response, the effect of intermittent dosing may persist for longer than 24 hours, continuous daily use not recommended; maximum 1 dose per day.

If you have any concerns, know that we are experts at prescribing for erectile dysfunction online, and will ensure it's safe for you and give all the advice and guidance you need. We are here for you.

What are the differences between ED medicines?

Medications for erectile dysfunction; such as Sildenafil (Viagra), Tadalafil (Cialis), Vardenafil (Levitra) all work similarly to each other but there are subtle differences with how quickly it works and it’s duration. Sildenafil for example is known to last for 4 hours whereas Tadalafil is known to last upto 36 hours. Some men prefer certain brands from experience whilst others may choose a certain brand to suit their sex lives. We would generally recommend Tadalafil for men who would like to achieve spontaneous erections and have desire for sex more than twice a week. There are numerous research conducted to suggest that Tadalafil is highly effective, having the additional benefit of improved tolerability, faster and sustained effectiveness which position it to be the treatment of choice for patients who prefer spontaneity in their life.

How long does Tadalafil work for?

The maximum effect is between 30 minutes to 6 hours (average: 2 hours) and works independently of food.
Half of the drug has left the bloodstream after 17 hours.
Tadalafil remains in your system and is effective for 36 hours.


If present, side effects from taking Tadalafil are usually mild and temporary.

The most common side effects of Tadalafil are: headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, vision changes (such as having a blue color tinge, or blurred vision).

Please read the patient information leaflet carefully for a full list of side effects and advice.

Cautions & Getting the most out of the treatment

Do not take more than one dose of Tadalafil in a 24-hour period, and take it as prescribed.

Tadalafil will only work if you are sexually aroused, so you still need to engage in some foreplay if you want it to work.

Having a large meal with Tadalafil may slow down the absorption and so it may take longer to have an effect.

Do not drink large amounts of alcohol or take recreational drugs before you plan to take sildenafil. Drinking too much alcohol can reduce your ability to get an erection and this may prevent you from getting the maximum benefit from the tablets. Drinking excessive amounts of alcohol with Tadalafil could also result in your blood pressure to drop dangerously low.

It is recommended that you do not drink grapefruit juice with Tadalafil. This is because grapefruit juice can increase the amount of Tadalafil in your bloodstream and this makes side-effects more likely.

You should not take Tadalafil if you are using any other products or taking any other medicines to treat erectile dysfunction.

Who should not take Tadalafil?

Women or children

Men for whom sexual activity may be inadvisable. These men should be referred to their doctor. This includes men:

  • whose doctor has advised that they are not fit enough for any physical and/or sexual activity.
  • who feel very breathless or experience chest pain with light or moderate physical activity, such as walking briskly for 20 minutes or climbing two flights of stairs.
  • who have had a recent (6 months) acute myocardial infarction (AMI) or stroke.

Men who have any other heart problems or are under a doctor’s care for any of the following:

  • Low blood pressure or uncontrolled high blood pressure.
  • Unstable angina (chest pain), irregular heartbeat or palpitations (arrhythmia).
  • A problem with one of the valves in the heart (valvular heart disease).
  • A problem where the heart muscle becomes inflamed and does not work as well as it should (cardiomyopathy).
  • Heart problems causing blood flow issues (e.g. left ventricular outflow obstruction, aortic narrowing) or severe cardiac failure.
  • Men with hypersensitivity to the active substance or to any of the excipients.
  • Men taking nitrates (nicorandil or other nitric oxide donors e.g. glyceryl trinitrate, isosorbide mononitrate or isosorbide dinitrate) for chest pain
  • Men taking ‘poppers’ for recreational purposes (e.g. amyl nitrite)
  • Men taking riociguat or other guanylate cyclase stimulators for lung problems
  • Men taking ritonavir (for HIV infection)
  • Men taking CYP3A4 inhibitors, e.g. saquinavir (to treat HIV infection), cimetidine (a heartburn treatment), itraconazole or ketoconazole (to treat fungal infections), erythromycin or rifampicin (antibiotics) or dilitiazem (for high blood pressure)
  • Men taking alpha-blockers, such as alfuzosin, doxazosin or tamsulosin, which are medicines to treat urinary problems due to enlarged prostate (benign prostatic hyperplasia) or occasionally to treat high blood pressure
  • Men with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie's disease)
  • Men who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy (NAION) or known hereditary degenerative retinal disorders such as retinitis pigmentosa
  • Men with galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption
  • Men with previously diagnosed hepatic disease or severe renal impairment
  • Men with any of the following: sickle cell anaemia, multiple myeloma or leukaemia men with any bleeding issues (e.g. haemophilia) or that have active stomach ulcers women
  • Men without erectile dysfunction
  • Men under 18 years of age
What else do I need to read?

Please read the 'Patient Information Leaflet' supplied with your medication. This provides important information.