Medication

How does Mounjaro work for weight loss?

Mounjaro reduces your appetite and helps you feel fuller for longer, helping you lose weight. Here’s the science behind how it works.

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Medically reviewed by Dr Earim Chaudry

Chief Medical Officer

iconPublished 6th December 2024
Research-Based Guide

Stephen lost 77 lbs this year with the help of Voy programme.

"With Voy, it’s not just about losing weight, it’s about building habits that last so the weight stays off for good. That’s the best thing about it."

Symptom
Lower sex drive
Fewer/weaker morning erections
Erectile dysfunction
Persistent fatigue/low energy
Loss of muscle/strength
Increased belly fat/weight gain
Low mood/irritability
“Brain fog”/poorer focus
Hot flushes/sweats
Smaller testes/fertility issues
Gynaecomastia (breast tissue)
Reduced bone density (longer term)
Approx. prevalence in men with low T*
50–70%
40–70%
40–60% (more likely when T is very low)
50–65%
40–60%
40–60%
20–40%
20–40%
5–20% (typically with more severe deficiency)
10–30% (varies with LH/FSH changes)
5–10%
10–30%
Features
How it works
What studies show
Speed
Hormones in blood
Side effects
Topical dutasteride
Applied directly to thinning areas on the scalp. Works mainly where you put it, with less effect on the rest of the body.
In studies, the 0.05% strength gave thicker, denser hair in 24 weeks and even outperformed oral finasteride.
Hair grows in slow cycles, so results take time.
Blood tests show only small changes in hormones, which may mean a lower risk of whole-body side effects.
Side effects are usually mild and limited to the scalp (such as irritation or dryness).
Oral dutasteride
Taken as a capsule by mouth. Circulates throughout the body, lowering DHT everywhere.
Has shown strong regrowth in several trials and, at higher doses, can outperform finasteride.
Results also build gradually, though some people feel they notice changes sooner.
Causes bigger drops in DHT and slight hormone shifts, which can raise the chance of whole-body side effects.
Side effects are more often reported than with topical use, including sexual side effects and mood changes (in a minority of men).

Benefits of Mounjaro

Mounjaro shows impressive weight loss results compared to lifestyle changes alone. The placebo group in the SURMOUNT-1 trial only lost 2.4% of their body weight in 72 weeks, compared to 16% for those on the lowest dose of Mounjaro.

Mounjaro also helps regulate your blood sugar levels, meaning your energy will be more balanced throughout the day and you won’t succumb to the same crashes and spikes. Finally, it reduces hunger and curbs cravings, quietening down any mental chatter around food.

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Mounjaro side effects

Like any medication, Mounjaro comes with potential side effects, although in most cases these are short-lived, mild and manageable.

The most common side effects include:

  • Gastrointestinal side effects (burping, flatulence, constipation, diarrhoea, nausea and vomiting)
  • Mild weakness or fatigue
  • Feelings of malaise
  • Dizziness
  • Hair loss
  • Low blood pressure
  • Injection site reactions like irritation, itching and bruising.

Most of the time, these side effects will subside as your body gets used to the medication.

Very rarely, users may experience more serious side effects including:

  • Gallbladder disorders
  • Very low blood sugar
  • Pancreatitis
  • Kidney disease
  • Allergic reactions.

How to take Mounjaro

Mounjaro is taken as a once-weekly injection, using your pre-filled four-dose KwikPen. The Mounjaro should be injected into your upper leg, abdominal area or upper arm. You can opt for the same body part every time, but make sure to choose a different injection site within that area. Wash your hands before starting, then follow the ‘Instructions for Use’ to administer your dose.

Although it’s important to try to take Mounjaro on the same day every week, don’t worry too much if you miss a dose. You can take it as soon as you remember, so long as it’s within four days of your scheduled day. Any longer than that, and you should skip the dose.

Make sure to only take the dosage recommended by your doctor. Typically, you’ll start on 2.5mg a week for the first four weeks, before adjusting your dose in 2.5mg increments. If you accidentally take too much, speak to your doctor.

Is Mounjaro available on the NHS?

Mounjaro is not yet available on the NHS for weight loss, although the government has announced that it will soon begin a gradual rollout. It will initially be made available to people with a BMI over 40, along with three or more weight-related health problems. After that, it will be offered to other groups in priority order of clinical need.

In the meantime, Mounjaro can be accessed privately through clinics or weight loss management services like Voy. Voy combines clinically proven medication and lifestyle coaching to help you achieve weight loss that sticks.

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