TRT

Testosterone gel (Testogel) for men

Here’s the lowdown on Testogel, a type of topical testosterone replacement therapy

clinician image

Medically reviewed by Medical Director

iconPublished 30th October 2025

All types of testosterone replacement therapy (TRT) work to increase T levels. Yet they aren’t all the same. Some are easier to use while others are more effective.

Here’s what to know about Testogel, aka testosterone gel for men.

Key insights

  • What is it: Testosterone gel
  • How it’s used: Applied to upper shoulders or arms once per day
  • Who it’s for: Men with confirmed low testosterone
  • Pros: Avoids needles
  • Cons: Can cause skin irritation, risk of transferrance
  • Availability: NHS or private prescription

What is Testogel?

Like all forms of TRT, Testogel is a synthetic version of testosterone. It’s a gel that you apply to your skin.

Testogel is a prescription-only medicine for men with clinically low testosterone.

How does Testogel work?

It delivers T through your skin.

The gel contains alcohol, which allows testosterone to be absorbed into your skin’s outer layer. It then gradually diffuses into your bloodstream over the course of several hours.

How long does testosterone gel take to work?

Men usually notice improvements in their low T symptoms within 3 to 6 months. Though it can take up to 12 months to see the maximum benefits.

Typically, energy, mood, and libido levels are the first symptoms to improve. Muscle mass and bone density are some of the slowest.

Head’s up: it’s important to check in regularly with your provider while using TRT, so they can monitor how you’re responding to the medicine.

Feeling drained and unfocused?
It might be low testosterone. Get answers fast with an at-home blood test.

Who is Testogel for (and who should avoid it)?

Testogel is for men who have confirmed low testosterone. But you shouldn’t use it if you have prostate or breast cancer.

Before starting Testogel, tell your provider if you have:

  • An enlarged prostate
  • Bone cancer
  • High blood pressure
  • Severe heart, liver, or kidney disease
  • Blood clotting issues
  • Epilepsy
  • Migraines
  • Difficulties breathing while you sleep

They’ll consider this when deciding whether the benefits of the treatment outweigh the risks for you.

Testogel can be a good option for people who want to avoid needles. But you have to apply it once (sometimes twice) per day, compared to a few times a week or month for injections. Plus, with gels, absorption of T tends to be low. They aren’t as effective as injections at driving up T levels.

Testogel formats and dosages

In the UK, Testogel comes in sachets or a pump dispenser.

For sachets, the recommended dose is 5g of gel (which contains 50mg of T) once per day. Your clinician might suggest increasing it to 10g (100mg T) daily.

And with pumps, the standard dose is two pumps of the medicine applied once per day (40.5mg T). Again, your clinician might increase this to three (60.75mg T) or four pumps (81mg T) per day.

How and where to apply testosterone gel

Applying the gel is pretty straightforward. Here’s how:

  • Choose when you’ll take it. This should be roughly the same time each day.
  • Apply the gel in a thin, even layer over both shoulders or upper arms (absorption is better in those areas). No need to rub it in. Your skin should be clean, dry, and healthy.
  • Wash your hands with soap and water. This prevents you from transferring the medicine to others.
  • Let the gel dry for about 3-5 minutes before putting clothes on.
  • Keep the area dry for at least an hour.

This is important: if you come into contact with others after applying the gel, there’s a risk that it will be transferred onto their skin and cause side effects. To avoid that, wash the application site with soap and water at least an hour after applying and then cover the area with clean clothes.

Testogel side effects

Most men tolerate testosterone replacement therapy with minimal side effects. But Testosterone gel side effects can include:

  • Breast tissue growth
  • Blood becoming thicker
  • Mood changes
  • Acne

It might also cause skin irritation. And there’s the risk of Testogel being unintentionally transferred to someone else’s skin.

Buying testosterone gel in the UK

Testogel is available on the NHS, though you may need to be referred to a specialist. You can also get it via private prescription. Make sure you get your TRT from a registered provider: otherwise, there’s no guarantee it’s genuine and safe to take.

At MANUAL, we use a TRT cream that absorbs more effectively than gels.

Alternatives to Testogel

If testosterone gel isn’t a fit for you, there are also patches, creams, nasal spray, and injections. Other medicines like Clomiphene could help with low T, too.

But so you know: injections are usually recommended for most men as they’re the most effective.

Find out if you’re eligible for TRT by taking our quiz and doing our quick, at-home testosterone blood test.

A stronger, sharper you
Get your energy, drive and strength back, with a tailored testosterone plan built by leading TRT doctors.
icon
Effective personalised medication
icon
24/7 access to expert clinical team
icon
Regular health monitoring
icon
All-inclusive subscription - no extra costs
FAQ

FAQs about Testosterone gel (Testogel) for men

DisclaimerAt MANUAL, we ensure that everything you read in the Health Centre is medically reviewed and approved. However, the information provided is not meant to replace professional medical advice, diagnosis, or treatment. It should not be relied upon for specific medical advice.
References
icon¹

Borst, Stephen, and Yarrow, Joshua F. “Injection of Testosterone may be Safer and More Effective than Transdermal Administration for Combating Loss of Muscle and Bone in Older Men,” American Journal of Physiology - Endocrinology and Metabolismscribble-underline, vol. 308, issue 12, 2015:E1035–E1042 https://pmc.ncbi.nlm.nih.gov/articles/PMC6189635/

icon²

El-Osta, Austen, et al. “A Cross-sectional Survey of Experiences and Outcomes of Using Testosterone Replacement Therapy in UK Men.” Translational Andrology and Urologyscribble-underline, vol. 14, no. 4, 2025:1295-1307 https://pmc.ncbi.nlm.nih.gov/articles/PMC12170005/

icon³

Lakshman, Kishore M, and Basaria, Shehzad. “Safety and Efficacy of Testosterone Gel in the Treatment of Male Hypogonadism,” Clinical Interventions in Agingscribble-underline, vol. 4, 2009:397-412 https://pmc.ncbi.nlm.nih.gov/articles/PMC2785864/.

icon

Miller, Jodi, et al. “Pharmacokinetics and Relative Bioavailability of Absorbed Testosterone After Administration of a 1.62% Testosterone Gel to Different Application Sites in Men with Hypogonadism,” Endocrine Practicescribble-underline, vol. 17, issue 4, 2011:574-583. www.endocrinepractice.org/article/S1530-891X(20)41752-5/abstract.

icon

Pastuszak, Alexander W., et al. “Comparison of the Effects of Testosterone Gels, Injections, and Pellets on Serum Hormones, Erythrocytosis, Lipids, and Prostate-specific Antigen,” Sexual Medicinescribble-underline, vol. 3, issue 3, 2015:165-173 https://academic.oup.com/smoa/article/3/3/165/6956248.

icon

Saad, Farid, et al. “Onset of Effects of Testosterone Treatment and Time Span until Maximum Effects are Achieved,” European Journal of Endocrinologyscribble-underline, vol. 165, issue 5, 2011:675-685. https://academic.oup.com/ejendo/article/165/5/675/6677022.

icon

“Testogel 16.2mg/g gel,” Electronic Medicines Compendium, 2024. www.medicines.org.uk/emc/files/pil.8919.pdf. Accessed 20 Oct. 2025.

icon

“Testogel 50mg transdermal gel in sachet,” Electronic Medicines Compendiumscribble-underline, 2024 www.medicines.org.uk/emc/files/pil.6808.pdf. Accessed 20 Oct. 2025

We use cookies to analyse data and personalise your visit, learn more in our privacy policy