Filters

Testosterone Replacement Therapy

Testosterone Replacement Therapy - Anastrozole Treatment Plan


Anastrozole is typically used for the treatment of breast cancer in women. It works by reducing levels of oestrogen in the body. It does this by blocking aromatase, an enzyme that converts testosterone into oestrogen. In testosterone replacement therapy (TRT), it may be used in men who develop higher levels of oestrogen.


What is it?

Anastrozole is a type of medication called an aromatase inhibitor, which helps reduce levels of oestrogen in the body.

Why am I taking this medication?

Your doctor has noticed higher levels of oestrogen in your system. This can sometimes happen in men receiving testosterone replacement therapy (TRT), as some testosterone is naturally converted into oestrogen.

Higher levels of oestrogen can lead to unwanted symptoms, so your doctor has prescribed this medication to help bring levels back into a more balanced range. These symptoms can include fluid retention, mood changes, and reduced libido or erection quality.

Your doctor has recommended anastrozole as they believe it is the most appropriate option for you, based on your individual results and symptoms.

Why do I have this leaflet?

This leaflet is to give you more information about the use of anastrozole in men.

This medication is not licensed for use in men. Using a medication in a way that is not included in its licence is known as ‘off-label’ use. This is relatively common in medical practice.

While this specific use has not been formally licensed, it is supported by clinical experience and available evidence. Your doctor will only recommend it when they believe it is appropriate and safe for you.

Side-effects

Anastrozole can cause side effects, particularly if oestrogen levels become too low. These can include:

  • Reduction in bone density
  • Joint stiffness or pain
  • Low mood or irritability
  • Reduced libido or erection quality
  • Headache or dizziness
  • Nausea or stomach upset
  • Changes in appetite

(This list is not exhaustive. Please refer to the manufacturer’s leaflet for further details.)

If you notice any side effects, or any other symptoms that you think may be related to this medication, please contact your doctor.

If you decide that you would like to stop taking this medication, please discuss this with your doctor first. Stopping treatment may lead to a rise in your oestrogen levels.

As part of your care, we monitor your oestrogen levels and overall response to treatment with follow-up blood tests and reviews. This helps ensure the medication is working as intended and allows us to make any adjustments if needed.

Anastrozole is usually used for shorter periods. If longer-term treatment is required, your doctor may recommend additional monitoring, including checks on bone density.

Is there any evidence for its use in men?Yes. Anastrozole has been used in men in a range of clinical settings, including in those receiving testosterone replacement therapy. While this use is not formally licensed, there is clinical experience and published evidence supporting its use in selected patients.

If you would like to read more, further information is available in the following studies:


We use cookies to analyse data and personalise your visit, learn more in our privacy policy