Testosterone Replacement Therapy (TRT) medication can give you a whole new lease of life - helping you feel happier, stronger, and more normal again. After talking to you and carefully assessing your symptoms, your doctor has designed a personalised treatment plan that incorporates medication that will work specifically for you.

You have been prescribed Testosterone Clomid as per your treatment plan.

So that you can feel confident and comfortable using your medication, it is important that you take the time to read through this leaflet, watch the relevant videos, and book yourself in for an Injection Training Consultation.

How does Clomiphene (Clomid) work?

Clomiphene works to block oestrogen receptors in the hypothalamus and pituitary gland, this signals to the body to then produce more testosterone and boosts your natural testosterone levels.

How effective is TRT?

The treatment can provide benefits in all aspects of your life. 90% of patients see an improvement in their symptoms as early as the 3 month mark. In specific symptoms, those on TRT saw an 87% improvement in their libido and 86% saw improvements in their energy levels. The treatments can allow for over a 239% average increase in Total Testosterone levels.

When will I see results?

Most men on testosterone see results within the first 2-10 weeks after injecting. You may notice improved mood, energy, libido and sleep after a few weeks, with increases in muscle mass and memory from 6 weeks onwards.

The 6 week check-in questionnaire and 3 month blood tests are really important to ensure that your treatment is having the desired effect, and it allows your doctor to make changes to your dosage to ensure your testosterone and oestrogen levels are in the right ranges.

What is my dose?

Your doctor will review your dosing protocol during your consultation, and should provide these instructions to you so you know how to take your medication.

You will be started on a low dose and slowly titrated up based on your response to the medication in terms of benefits and potential side effects.

Your maintenance dose will usually be an alternate-day dose regimen.

Your doctor may recommend a higher dose of Clomid, such as 50mg daily, depending on a variety of factors, but this will be discussed during your consultations.

It is important to note that your doctor may also recommend that you stay on a LOWER dose for a longer period - this may be slightly different to the up-titration plan above.

If you have been prescribed a different dose to the titration plan above, please follow the instructions from the doctor.

If you get any side effects from your medication, please reduce to the previous dose that you were taking. Example: if you start to see side effects on the week 3 dose, please revert back to your week 2 dose and get in touch with the team.

It is important that you take the medication as prescribed by your doctor and avoid making any changes to this without speaking to the team first. Dosage adjustments will be made based on your Testosterone levels and side effects.

If you are stopping TRT and have been prescribed Clomid for this purpose, please follow the dosing instructions provided.

Blood test monitoring

Once you start treatment, you will have blood tests at different points in your journey. These tests are required, extremely important for your safety, and help us ensure your treatment is effective.

Whilst under our service, you have access to our specialist team and will have review consultations with your doctor to monitor your progress. At the start of treatment these monitoring tests and reviews are more frequent. You can find our monitoring test schedule below.

We will notify you via email and SMS when your next monitoring test is due, and you can organise them directly from the tasks/actions section of your account homepage.

We suggest you complete your monitoring blood tests as quickly as possible after notification to ensure continuity of treatment. If you do not complete the test within 5 weeks of being notified we will not be able to prescribe further medication until the tests are completed.

You can contact us at anytime if you need help purchasing or organising your tests, or with any help whilst reordering medications or supplies.

Is long term clomid use safe?

Current evidence suggests that Clomid is safe and effective. In addition, the British Society of Sexual Medicine lists Clomid as a safe alternative to TRT.

Who should NOT take Clomid?

If you have had your consultation and been started on Clomid, your doctor will have reviewed all potential contraindications.

There are three drugs that potentially interact with Clomid and if you are on any of these, please let us know and speak to your specialist who prescribed them:

• Abrocitinib (indicated for moderate/severe atopic eczema rarely used in the UK and only under dermatologist advice)
• Bexarotene (used in the treatment of cutaneous T-cell lymphoma)
• Fluoroestradiol F-18 (a dye used in PET scanners): If you require a PET scan, please discuss the fact you take Clomid at least 2 weeks before undergoing any imaging procedures.

How do I order more medication?

When you are running low on your medication or injection supplies, you will need to put in a request for top-ups and this will be reviewed and approved by your consulting doctor as long as your monitoring is up to date.

Medication is not dispatched automatically, but the form below can be used to order when needed:

What are the potential side effects?

The side effects of Clomid are usually dose dependent but it is important that you let us know if you think you are experiencing any side effects from the medication so we can manage your treatment plan accordingly to ensure you get the best response.

Side effects you may experience:

• Hot Flushes and headaches
• Changes in libido (sex drive)
• Changes in mood
• Changes in energy level
• Increased aggression
• Male-pattern baldness
• Blurred vision

Some of these side effects are similar to those from taking testosterone, however, unlike direct testosterone replacement, there should not be an adverse effect on your sperm count/fertility.

How does the subscription and payment work?

Importing medication such as HCG, and doctor fees are expensive. We have broken down these costs into a monthly subscription to make them more affordable for you.
Your monthly All-in-One subscription covers the cost of our systems, support teams, doctor consultations, your core medication, blood tests, clinic visits, injection supplies and travel letters.

Other addons for supportive medication are changed as extras should you need them.

What if your medical status changes?

If you start taking any new medications or if there are any significant changes to your medical history, please inform our clinicians/doctors via your patient account messaging facility. If you experience any significant side-effects or want any further advice on your treatment, please do let us know.

It is important that you inform your GP about the medicines you take to ensure they have an accurate medication history. If you do not share this information with your GP it could result in the healthcare professional not having enough information to make informed clinical decisions about your care, increasing your risk of injuries or side effects. On your account page, you can download a letter to share with your GP that contains all the relevant information about your treatment plan.

Please note that some of the TRT treatment plans may include off-label and unlicensed use of medication. This may include how the medication is injected or the dosage frequency. All medication prescribed is supported by research and years of clinical experience, which has demonstrated this to be a more effective method of treatment.

We're dedicated to continually improving our understanding of the medications we prescribe, including their side effects, to provide the highest level of care, guided by the latest medical insights. If you experience any side effects, please discuss them with your TRT Team.
You can also report side effects, no matter how minor, through the government-run Yellow Card reporting scheme at https://yellowcard.mhra.gov.uk/. Your input is vital for enhancing medication safety for all.